Germany scored five times in 27 minutes in the first half to crush Estonia 8-0 on Tuesday and make it three wins in three Euro 2020 Group C qualifiers.
The Germans are now on nine points, three behind group leaders Northern Ireland, who have four wins from four but needed an 86th minute winner by Paddy McNair to edge past hosts Belarus 1-0.
Their quick, flowing football gave their opponents no chance even when they piled 10 outfield players into the box.
Reus' second goal, a superb free kick from 20 metres, was Germany's first free kick goal since 2007.
The Germans are looking to rebuild after their woeful World Cup first round exit last year along with their Nations League relegation. They also beat Belarus 2-0 on Saturday.
"We wanted to score more goals than we did against Belarus and we managed that," Reus, who also hit the woodwork, told reporters.
"We did it very well in the opening half hour, we had really good rhythm and our passing game was outstanding."
Germany next play Netherlands on Sept 6 while Northern Ireland, who have won four games in a row at the start of a qualifying campaign for the first time, host Germany on Sept 9.